Microglial Dynamics Across the Lifespan

A new preprint article from Taryn Tieu and Prof. Vanessa Coehlo-Santos, during their time in the lab, uses high-resolution two-photon imaging to study the physiological and injury-induced dynamics of microglia across the life-span. Their results show how microglial in the developing brain are highly mobile but less coordinated in their response to tissue and vascular injury compared to the adult brain. In the aged brain, microglia mount coordinated responses to focal injury, but are slower and less sensitive.