Our research focuses on the small blood vessels that delivery oxygen and nutrients to the brain. In the adult human brain, an estimated 200-400 miles of vasculature delivers blood to 100 billion neurons. This immensely complex task can go awry during human disease. When we are young, genetic and environmental factors can compromise the normal development of brain vasculature. These changes may affect brain function later in life. As we age, leakage and blockage of small vessels can contribute to Alzheimer’s disease and related dementias. 

Our goal is to understand the fundamental mechanisms that control brain vascular function, and to unveil new strategies and therapeutic options for improving cerebrovascular health in brain diseases across the lifespan.